Resident Evil 6 allows players to select between four
scenarios with connected storylines, each with their own intentionally
different design. Each scenario follows one of four main protagonists -
Leon S. Kennedy, Chris Redfield, Jake Muller and Ada Wong. The player
characters from each scenario will have their own partners which are
controlled by either the computer AI or another human player via local
or online multiplayer. When playing in single player, the player can
allow another player to join in online at any time and inventories are
now kept separate from each other. and a fourth scenario, in which the player controls Ada Wong (with a partner).
The game also features the Mercenaries mode, where players fight hordes
of enemies, and the Agent Hunt mode which allows players to take
control of random enemies in other people's games.
Players can pick up items quickly and change weapons in real time.
Players are also able to move while aiming their firearms. A new feature
comes in the form of tablets, in which players can recover health at
the push of a button. More tablets can be produced by locating herbs. By
finding various herbs and saving them before converting, more tablets
can be obtained from them. If one player runs out of health, that player
will have a short time to try and defend him/herself while his partner
attempts to revive them. If either player is killed, gameplay resumes at
the last checkpoint. The game has several primary enemies, including zombies
and the newly introduced J'avo. Unlike zombies, J'avo are able to
interact with each other to plan an attack, use weapons, and heal
themselves.
Certain enemies drop skill points when killed, which can be picked up
and spent on upgrades such as increased weapon effectiveness or specific
ammunition drops. Players can equip three of these upgrades which apply
to all the campaigns. There are set piece events that require different
approaches, such as shooting at zombies, prying through a door, and
attempting to locate keys in a vehicle.